Formulated by Dr Joseph J Collins RN ND
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Science: The EstroMend™ Herbs
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Pueraria Root Extract
(Pueraria montana, Pueraria lobata,standardized to 40% isoflavones)
Isoflavones from Pueraria lobata have the ability to diminish menopausal symptoms and support maintenance of bone mineral density. These phytoestrogens may also help protect the cardiovascular system, support the immune system, inhibit angiogenesis, and protect against oxidative damage as antioxidants. (NutriNews)
Red Clover Extract
(Trifolium pratense, stem, leaves, and flowers, standardized to 8% biocannins)
Isoflavones from red clover (Trifolium pretense) have the ability to diminish menopausal symptoms and support maintenance of bone mineral density. These phytoestrogens may also help protect the cardiovascular system, support the immune system, inhibit angiogenesis, and protect against oxidative damage as antioxidants.  (NutriNews)
Bacopa Extract
(Bacopa monnieri, aerial parts, standardized to 20% bacosides)
Bacopa (Bacopa monniera) is an herb used in India as a brain tonic. It is used to enhance memory and to treat insomnia. Considered to be of great value for the aging brain, it is also used to promote longevity and recover from nervous deficits due to injury or stroke. Researchers have studied its potential to treat nervous breakdowns and exhaustion. While enhancing brain function it also has a mild sedative and tranquilizing effect. (DYMT pg 232)
Bacopa monniera mimics the abilities of estrogen to help the body adapt to both acute and chronic stress as well as maintain cognitive function. It does not bind to estrogen receptors and is not associated with estrogen receptors, suggesting functional mimetic attributes.  (NutriNews)
Gotu Kola Extract
(Centella asiatica, leaf, standardized to 10% asiaticosides)
Gotu kola is another herb used in India to improve memory and cognitive function. The research on centella and memory indicates that it is beneficial for both memory improvement and neuroprotection. Centella improves antioxidant function by increasing the activity of mitochondrial antioxidant enxymes (SOD, CAT, GSH, & GPx) as well as supporting the actions of nutrient antioxidants such as vitamin C and beta-carotene. There is also considerable research about centella and cancer protection, as well as centella and microangiopathy.
Hops Extract
(Humulus lupulus, strobiles, standardized to 5% alpha bitter acids)
Some of the compounds that occur naturally in hops have very strong phytoestrogenic activity. Recent research has even suggested that some of the compounds in hops have a preventive effect against breast and ovarian cancer. Hops also has sedative effects and can be used to reduce anxiety and irritability, or help induce sleep.  (DYMT pg 232)
The therapeutic effects that hops (Humulus lupulus) has in reducing hot flashes in menopausal women and its efficacy in mood disturbances such as restlessness, anxiety, and sleep disturbances appear to be due to the phytoestrogenic activity of constituents such as 8-prenylnaringenin.  (NutriNews)
Dong Quai Root Extract
(Angelica sinensis, standardized to 1% ligustilides)
Dong Quai (Angelica sinensis) has phytoestrogen activity and has been used to decrease the symptoms of menopause. Like many phytoestrogens, it has no true estrogen action, so may be considered safe for women who need to avoid steroid estrogens. It has antioxidant and anti-tumor activity which also can an additional benefit for women needing to avoid steroid estrogens. Don Quai is also a hematonic; a blood building herb used to treat anemia.
Don Quai has mildly sedative, tranquilizing and analgesic properties. It has anti-inflammatory and anti-allergic properties so effective, that it can be used to decrease sensitivity to dust, animal dander or pollen and can slow down progression of inflammation and fibrosis in affected lungs. Don Quai also decreases risk for heart disease.
This herb is well known for its ability to increase vaginal lubrication and may increase sexual activity. It will also moisten the intestines and help move the stool; its ability to increase intestinal mucus may make it mildly laxative. Due to its effect on this intestines it may increase flatulence, and should be used with a carminative such as sage. Don Quai is a good herb for all woman in which estrogenic action is desired, while steroid estrogens are avoided or not fully effective.  (DYMT pg 232)
Don Quai (Angelica sinensis) has weak estrogen receptor binding capacity and may be considered a phytoestrogen which may explain its traditional use to increase vaginal lubrication, though it does not produce estrogen-like responses in endometrial thickness. The action of increased bone formation by ferulic acid, a constituent of Don Quai, is different from the actions estrogens, suggesting functional mimetic of estrogen properties.  (NutriNews)
Schizandra Fruit Extract
(Schizandra chinensis, standardized to 9% schisandrins)
Schisandra (Schisandra chinensis) is an adaptogenic herb that has been used to treat insomnia, irritability and forgetfulness, while at the same time being effective against fatigue exhaustion. It improves concentration, coordination, vision, hearing and sense of touch. It is also used to treat spontaneous sweating. Its adaptogenic actions appear to influence the brain the most. This herb is of use when there is decreased nervous system function, especially due to estrogen deficiency.  (DYMT pg 232)
The neuro-cognitive supporting actions of Schisandra (Schisandra chinensis) may be associated with its affect on serotonin and GABA receptors, while its ability to manage cardiovascular symptoms, especially those associated with menopause, may be attributed to its ability to activate estrogen receptors and affect nitric oxide-mediated vasorelaxation. Thus, Schisandra may express phytoestrogen properties, and be a functional mimetic of estrogen in regard to serotonin and GABA receptors.  (NutriNews)
Sage Leaf
(Salvia officinalis)
Sage (Salvia officinalis) contains estrogen-like substances that make it useful for women. It has been used to treat a wide range of menopausal symptoms including hot flushes and mood swings due to hormone changes. It has the ability to decrease perspiration, and can may be of value when treating hot flush.  (DYMT pg 232)
Sage (Salvia officinalis) contains phytoestrogen substances that are effectively used to treat hot flashes and to decrease perspiration in both daytime and night-time excessive sweating. The positive effects of Sage on the nervous system include both memoryimproving properties and calming actions, the later of which have been attributed to its ability to bind to the GABA/benzodiazepine receptor complex in brain tissue.  (NutriNews)
Black Cohosh Extract
(Cimicifuga racemosa, root and stem, standardized to 8% triterpene glycosides)
Black Cohosh (Cimicifuga racemosa) has an ability to decrease hot flushes and other symptoms of menopausal discomfort. Its estrogen-like activity makes it ideal for treating estrogen deficient types of menopause. The estrogen-like activity of Cimicifuga does not stimulates uterine tissues the way estrogen does, so lacks the complete properties of estrogen in this sense. None-the-less, it is effective in increasing blood flow to the pelvic area, and relieves spasms, cramps and inflammation. It also has a mild euphoric effect, resulting in mood elevation and control of menopause related depression. Perhaps this ability to relieve symptoms, without having a complete hormone effect is why Cimicifuga is considered so safe and effective that it may be a good alternative to estrogens replacement therapy for women who wish, or need, to avoid estrogen.  (DYMT pg 232)
Though black cohosh (Cimicifuga racemosa) has periodically been described as having phytoestrogen properties, due to its ability to diminish menopause symptoms that are associated with estrogen deficiency, we now know that Cimicifuga racemosa does not universally bind to either of the known estrogen receptors, though it may have selective estrogen receptor modulator (SERM) activity specific to bone and hypothalamo/pituitary tissues.  (NutriNews)
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EstroMend™ was developed by Dr. Joseph J Collins, RN, ND, to improve the specific functions of estrogens. Based on Dr. Collins’ phytocrine™ model of phytotherapy, EstroMend™ was formulated based on years of clinical experience, validated by review of published international scientific/medical research.

EstroMend™ is composed of ten specific herbal extracts. The science associated with most of the herbal extracts has been presented in the book, Discover Your Menopause Type (DYMT pg #, with additional information in the Phytotherapeutic Management of Endocrine Dysfunctions NutriNews.
A Hormone Specific Formulation
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